Lab+Life Scientist - December 2018-January 2019.pdf

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Publish with confidence
Around half of the money spent on protein-binding reagents globally is wasted
due to non-specific and inconsistent antibodies
1
. Simply offering replacements is
not good enough. Your results are too important for uncertainty.
Antibodies validated in knockout cell lines, which do not express the protein of
interest, provide a true negative control and guarantee specificity.
See how at:
www.abcam.com/validation
KO validated
using knockout-validated antibodies
1. Bradbury, A. and Plückthorn, A. 2015. Reproducibility: Standardize antibodies used in research. Nature. 518(7537), pp.27-29.
dec 18/jan 19
Contents
06
Lorne 2019
6 SOLvINg ThE
gENETICS puzzLE
Renowned Australian geneticist
Melanie Bahlo on solving the puzzle
of neurological diseases with
statistical genetics.
25 AI MEETS IMAgE
ANALySIS AT ThE
uNIvERSITy OF
ADELAIDE
Researchers are creating
technology that is claimed to
“compete with, and sometimes
exceed, human capabilities in tasks
like recognition, statistical analysis
and classification”.
12 TRIM21 AND
ANTIBODy IMMuNITy
Dr Leo James from the MRC
Laboratory of Molecular Biology
(LMB) on host-pathogen interaction
and TRIM21.
30 DIRECTED EvOLuTION
Nobel Laureate professor Frances
Arnold will deliver a special evening
lecture on protein engineering at the
44th Lorne Conference on protein
Structure and Function.
12
15 INFECTION AND
IMMuNITy
Lorne Infection and Immunity
Conference 2019 is a
multidisciplinary, international
conference will bring together
basic and clinical researchers
from immunology, microbiology
and related fields, in academia
and industry, working in human
and animal health, host-pathogen
interactions, innate and adaptive
immunity, and infectious and
inflammatory diseases.
35 CELL SuICIDE
Researchers have discovered a
mechanism that eliminates T cells
that pose autoimmune dangers.
38 uSINg AuTOMATION
TO FAST-TRACk
COMMERCIALISATION
when it’s time to move
biotechnology breakthroughs
towards commercialisation, specific
application workflows may require a
custom approach to lab automation.
22
22 BETTER BLOOD
ANALySIS wITh LAB-
ON-A-ChIp DEvICES
Dr warwick Nesbitt is on a mission
to bring blood analysis out of the
pathology lab, developing a family
of lab-on-a-chip devices in an
effort to improve blood handling,
diagnostics and drug development.
25
Cover image © stock.adobe.com/au/Siarhei
READ ONLINE!
www.LabOnline.com.au | www.LifeScientist.com.au
This issue is available to read and download at
www.labonline.com.au/magazine
LAB+LIFE SCIENTIST - Dec 2018/Jan 2019
|
3
editorial
Welcome to
Lab+Life Scientist’s
first issue for
2019. I hope you had a wonderful holiday period
and start to the new year!
This much-awaited Lorne series of
conferences — Lorne Proteomics; Lorne
Protein Structure and Function; Lorne Cancer
Conference; Lorne Infection and Immunity
Conference; Lorne Genome Conference — will
begin in a few weeks. This issue features some of
the speakers presenting at the conferences. In the
lead article, award-winning, Australian geneticist
Melanie Bahlo — who is presenting at the 2019
Lorne Genome Conference (17–19 February) —
provides insights on novel statistical techniques
that are helping find genetic causes of diseases.
Professor Frances Arnold from the California
Institute of Technology, a joint winner of
the 2018 Nobel Prize for Chemistry, is one of
the international speakers at the 44th Lorne
Conference on Protein Structure and Function
(10–14 February). She’ll talk about protein
engineering, key developments in the field and
her contributions to the field. To read more on
the topic, please visit page 30.
Another interesting speaker at the Lorne
Proteins conference is Dr Leo James from the
MRC Laboratory of Molecular Biology (LMB).
Dr James and his team, along with scientists
from the Max Planck Institute for Biophysical
Chemistry, have recently developed a method
called Trim-Away, which makes it possible to
directly target almost any protein in any type of
cell. At Lorne, Dr James will talk about TRIM21,
a protein — discovered at his lab — that was key
to the development of the new method.
In this issue, we also report on a number of
other interesting projects and developments in
Australia and overseas. For example, the article
on page 22 features a lab-on-a-chip device that’s
improving blood handling, diagnostics as well as
drug development. He recently received funding
from the NHMRC for the project.
Stanford and SLAC National Accelerator
Laboratory researchers are working on two
potential treatments — one using X-rays, the
other using protons — that aim to reduce the side
effects of radiation therapy by vastly shrinking
the length of a typical session. The idea behind
both is to blast cancer cells so quickly that
organs and other tissues don’t have time to move
during the exposure — much like taking a single
freeze frame from a video. To read more on the
treatments, please visit page 10.
If you’re working on an interesting project,
have launched a new product, would like to
contribute an article or want to provide feedback,
please send me an email at mgandhi@wfmedia.
com.au.
Regards,
Mansi Gandhi
LLS@wfmedia.com.au
Mansi Gandhi
4
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LAB+LIFE SCIENTIST - Dec 2018/Jan 2019
www.LabOnline.com.au | www.LifeScientist.com.au
© stock.adobe.com/au/bluebay2014

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